ISSN 1662-4009 (online)

ey0015.12-5 | New Mechanism | ESPEYB15

12.5 Role of DNA Methylation in Type 2 Diabetes Etiology: Using Genotype as a Causal Anchor

HR Elliott , HA Shihab , GA Lockett , JW Holloway , AF McRae , GD Smith , SM Ring , TR Gaunt , CL Relton

To read the full abstract: Diabetes 2017;66:1713-1722This study examined whether genetic variants predisposing to T2DM exert their influence on disease via changes in DNA methylation in a young, non-diabetic, cross-sectional cohort. The examination of young subjects who are disease-free enables exploration of SNP-methylation relationships without assessing methylation differences that result from rev...